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Hand-picked AI open-source projects on GitHub worth following: LLMs, agents, RAG, local deployment, image and speech… 1052 projects so far.

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All 1052🧠 Large Language Models 26🤖 AI Agents 162🧩 App Development Platforms 23📚 RAG & Knowledge Bases 48💬 Chat UIs & Clients 42🖥️ Local Inference & Deployment 86👨‍💻 AI Coding 98🛠️ Frameworks & SDKs 48🔌 MCP & Tool Ecosystem 35🎨 Image Generation 26🎬 Video Generation 17🎙️ Speech & Audio 46👁️ Computer Vision 27📄 Document Parsing & Scraping 25🗄️ Vector Databases 27🏋️ Training, Fine-Tuning & MLOps 74🧪 Evaluation, Observability & Safety 80🚪 API Gateways & Proxies 11🔎 Search & Deep Research 13⚙️ Deep Learning Libraries 59🏷️ Data & Annotation 32🔬 Industry & Science AI 35⚡ Productivity Tools 12
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General plug-and-play inference library for Recursive Language Models (RLMs), supporting various sandboxes.

🤖 AI AgentsPython★ 5.7k

⚡️next-generation personal AI assistant powered by LLM, RAG and agent loops, supporting computer-use, browser-use and coding agent, demo: https://demo.openagentai.org

💬 Chat UIs & ClientsAgentLangChainLLM★ 5.7k

Local-first healthcare AI: clinical NER and HIPAA PII de-identification on hardware you control. 2,200+ medical models, 35 model-backed PII languages, and Python, MLX, Android and browser runtimes. Apache-2.0 SDK.

🔬 Industry & Science AIPythonLLMLocal deployment★ 5.7k

A terminal window manager that knows what your agents are doing. Tiling panes, workspaces, sessions that survive restarts, and one Inbox for every coding agent.

👨‍💻 AI CodingGoAgent★ 5.6k

The Harness of Harnesses • built for RSI: a trusted, persistent, self-evolving multi-agent ecosystem for all-domain collaboration.

🤖 AI AgentsPythonAgentLLM★ 5.5k

Peekaboo is a macOS CLI & optional MCP server that enables AI agents to capture screenshots of applications, or the entire system, with optional visual question answering through local or remote AI models.